Don’t Miss the 49ers vs. Cardinals Showdown This November 16 — Here’s Every Way to Watch Live Without Missing a Second.QQ
By Data Skrive
Nov. 12, 2025Updated Nov. 13, 2025 11:11 pm GMT+7
On Sunday, November 16, 2025, the Arizona Cardinals (3-6) host an NFC West bout against the San Francisco 49ers (6-4) at State Farm Stadium.
How to watch San Francisco 49ers vs. Arizona Cardinals
- Venue: State Farm Stadium
- Time: 4:05 p.m. ET
- Streaming (in-market viewers): Fubo (Stream now)
- TV: FOX
- Watching in person? Get tickets on StubHub.
San Francisco vs. Arizona odds
- Spread: San Francisco -2.5 (-120), Arizona +2.5 (+100)
- Favorite Moneyline: San Francisco -155
- Underdog Moneyline: Arizona +130
- Total: 48.5
- Total Over Odds: -110
- Total Under Odds: -110
Odds provided by BetMGM.
Injury reports
49ers
QB Mac Jones: Full Participation in Practice (Knee)
QB Brock Purdy: Limited Participation in Practice (Toe)
WR Ricky Pearsall: Limited Participation in Practice (Knee)
LB Dee Winters: Limited Participation in Practice (Knee)
DT Alfred Collins: Limited Participation in Practice (Hip)
OT Trent Williams: Did Not Participate In Practice (Rest)
RB Christian McCaffrey: Did Not Participate In Practice (Rest)
Cardinals
CB Will Johnson: Did Not Participate In Practice (Back)
WR Xavier Weaver: Limited Participation in Practice (Ankle)
DL Darius Robinson: Limited Participation in Practice (Groin)
OLB BJ Ojulari: Limited Participation in Practice (Knee)
WR Marvin Harrison Jr.: Did Not Participate In Practice (Illness)
DL Walter Nolen: Limited Participation in Practice (Knee)
OLB Baron Browning: Did Not Participate In Practice (Concussion)
CB Max Melton: Limited Participation in Practice (Concussion)
RB Bam Knight: Limited Participation in Practice (Ankle)
OL Kelvin Beachum: Did Not Participate In Practice (Groin)
OL Will Hernandez: Limited Participation in Practice (Knee)
OL Evan Brown: Limited Participation in Practice (Foot)
LB Mack Wilson: Did Not Participate In Practice (Ribs)
OL Jonah Williams: Did Not Participate In Practice (Shoulder)
S Dadrion Taylor-Demerson: Did Not Participate In Practice (Ankle)
DL Bilal Nichols: Did Not Participate In Practice (Personal)
Stats to know
- The 49ers’ average points scored this season (22.0) and the Cardinals’ average points allowed (23.9) are within 1.9 points.
- San Francisco’s offense has averaged 356.2 yards per game this season, within 16.8 yards of the 339.4 Arizona’s defense has allowed. SF picks up 5.7 yards per play and Arizona gives up 5.6.
- The Cardinals’ average points scored this year (22.4) and the 49ers’ average points allowed (23.0) are within 0.6 points.
- San Francisco’s defense has allowed 339.4 yards per game in 2025, 23.1 yards more than the 316.3 Arizona’s offense has averaged. Arizona gains 5.4 yards per play and San Francisco gives up 5.6.
This watch guide was created using technology provided by Data Skrive.
Betting/odds, ticketing and streaming links in this article are provided by partners of The Athletic. Restrictions may apply. The Athletic maintains full editorial independence. Partners have no control over or input into the reporting or editing process and do not review stories before publication.
